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It seems that heart pumps 2,000 gallons of blood flowing through the 60,000 miles of blood vessels that feed our organs and tissues. Any damage to the heart or its valves can reduce that pumping action, forcing the heart to work harder just to keep up with the body's demand for blood. Poets say "The best and most beautiful things in the world cannot be seen or even touched - they must be felt with the heart". Clinicians and Scientists advice to change the brand of cooking oil periodically or stick to the use of olive oil alone to keep a healthy heart. At this juncture, I would like to take you all to think a bit ahead of your knowledge in the direction of genomics and regenerative therapy for cardiovascular diseases (CVDs).

While walking on the river side, my grandfather who was a farmer told me during my childhood that it is very difficult to kill a tree. The logical reason is that the tree is deeply rooted and cutting the trunk at the ground level doesn’t help. Being a researcher, I realized that it is easy to kill a tree than a cancerous cell that freely floats in our body...

No two individuals are phenotypically identical. Seldom if they are identical by genotypes too , their individual biochemistr y may differ subject to predisposition to different environments. One should definitely know why one human is different from other or why one human is more susceptible.

Evolution is an ongoing process. Change and transformation is inevitable for every organism including man. It is imperative for us to realize that only humans have acquired the unique capability of rationale thinking and decision making for sustenance and survival. Our world is bestowed with different languages and cultures. While philosophical poets quote that music and nature have no language, the scientic poets claim that we are all governed by the universal language of DNA made of just four letters A, T, G and C that determine what we are, how we are and why we are unique from each other.

In the current issue of Transcomm, we try to shed light on the effects of sleep or lack thereof on stem cells and their properties. We are sure the reader while appreciating the various uses of stem cells in modern medicine would realize the importance of incorporating ample amount of sleep in their daily life to maintain their overall health and wellbeing.

While the early efforts in harnessing the enormous potential of stem cells for treating disease were largely focused on regeneration and the ability to repair damaged tissues in the body, recent advances in this field started driving researchers and clinicians alike to employ stem cells in drug discovery applications, such as novel compound screening, toxicity testing, target identification, disease modeling and personalized medicine development.

Therapeutic nihilism refers to the "skepticism regarding the worth of therapeutic agents especially in a particular disease". The view that the era of modern medicine began with the introduction of the sulfonamides is supported by a standard textbook of pharmacology that refers to the years 1908-35 as being characterized by "therapeutic nihilism". The failure of several promising drugs in the clinical trial stages led to a sense of therapeutic nihilism in big pharma about the prospects of using chemical and biologics as effective treatment modalities.

Mesenchymal stem cells (MSCs) are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types. The effectiveness of MSCs based therapies is dependent on a gamut of factors which include differentiating state of the MSCs at the site of application, vehicle used and the nature/extent of injury. Tissue engineering and regenerative medicine, coupled with genetic engineering and gene therapy are revolutionizing the way cell therapy is performed these days.

Prometheus is a Titan in Greek Mythology, best known as the creator of mankind and it’s greatest benefactor. He transgressed the law of gods and stole fire from Mount Olympus for the sake of humankind, for which he received a brutal punishment from Jupiter. Jupiter had him chained to mount Caucasus, where a vulture would prey on his liver daily. Legend has it that his liver renewed as quickly as it was devoured, which captures the body’s remarkable regenerative capacity.

Teeth, which happen to be the most natural and noninvasive source of stem cells owing to their convenience and affordability to collect hold promise for a range of difficult to treat medical indications.

An orphan disease is a rare disease (according to US criteria, a disease that affects fewer than 200,000 people) or a common disease that has been ignored. But, the true definition not known by many is that a disease category that has not been taken up by any pharmaceutical industry to research on as it provides little financial incentive for the private sector to make and market medicines to treat or cure.

In the United States alone, some 800,000 people suffer from a brain stroke each year and close to 7 million are chronic stroke patients. With a population of 1.5 billion the burden of stroke on Indian society is considered to be significant. Increasing incidences of lifestyle diseases like diabetes and hypertension are also triggers for stroke in men and women.

The human body, having deployed its white blood cells (WBCs) to the battleground, is in a state of perpetual war against microbes, foreign substances and potentially neoplastic cells. A subset of WBCs survey the the entire body through tunnels called blood vessels or guard specific tissues and provide constant reassurance of safety. Together, they form one of the strongest components of the immune system and are well equipped to handle pathogens that may have breached the primary barriers of defence, such as skin. A defect in the development of these cells would leave the body unprotected and susceptible to various infections.

Although initially confined to narrow spaces within bones, Hematopoietic Stem Cells (HSCs) can mobilise, divide and differentiate to produce over 55 percent of the blood volume and the body’s strongest defense against microorganisms and cancer cells.

Right kind of information dissemination and meta-analysis of the clinical data published in the public domain play significant role in bridging the gaps to discover the unknown. Our newsletter will keep the users of banking facilities with the late stdevelopments . Transcomm will forward the developments and innovations to reflect translations focused on applications to